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Although in established tumors FASN upregulation has been described as a “cancer autonomous” system to generate its own lipid pools 1,37,38 , in the proposed model the requirement of FASN by transforming cells would be unrelated to the enzymatic product

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Thus transfer from blood to brain and CSF occurs across these interfaces and is known to be present from early stages of brain development for a wide range of metabolically important molecules: glucose (Dermietzel et al., 1992