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There is a close relationship between MSU crystal deposits and the development of cartilage and bone erosions.[75] Tophi contribute to joint damage and bone erosion in gout.[76] At the bona and a tophus interface, MSU crystal deposits are surrounded by osteoclast-like cells.[77] T-cells within the tophus express the receptor activator of nuclear factor κB ligand (RANKL), contributing to bony erosions