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(143) found that catechol modulates the reduction in intracellular calcium levels in platelets, which led to Ca 2+ -ATPase activation and the inhibition of IP3 production, thereby inhibiting fibrinogen-GPIIb/IIIb binding and reducing platelet aggregation

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However, HDAC6 inhibitors are poorly soluble in water which restricts their bioavailability and BBB permeability