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In normal conditions, this protein is present in low amounts in the circulation, but upon damage to the intestinal barrier, it is released into the bloodstream ( A limited number of studies have reported increased systemic levels of claudins as a marker for impaired intestinal barrier function, e.g., increased serum claudin-5 in children with attention deficit hyperactivity disorder ( Finally, zonulin has become a widely used biomarker for intestinal permeability