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ROS not only directly oxidize tight junction proteins, inducing conformational changes and functional impairment, but also upregulate the expression and activity of MMP-9, thereby establishing a positive feedback loop that markedly accelerates the disintegration of tight junctions (152)

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[DOI] [Google Scholar] 52.Liu D., Xu L., Chen L., Hu J., Wu D., Wang G., Shen H., Zhang X., Ji Y., Ruan L