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Kitajima et al.[27] observed a frequency of fibrosis, identified by Masson’s trichrome stain, equal to 80% in the cortical tissue of ovaries with OMA and 27% in the healthy ovaries, contralateral to the lesion

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23-26 In addition to their beneficial impact on intestinal disease activity, the anti-TNF agents can also be effective against a number of the joint, skin, and eye extraintestinal manifestations (EIMs) and, as such, may be preferred advanced therapies in patients with those particular manifestations