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3.3.1 Parkinson’s disease (PD) The primary pathologic hallmarks of PD are loss of dopaminergic neurons located in an area of the brain called the substantia nigra pars compacta, and the presence of Lewy bodies, intracellular aggregates of misfolded α-synuclein, in dopaminergic neurons and likely contribute to the death of these neurons
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Plant-derived polyphenols, including resveratrol, quercetin, and epigallocatechin gallate (EGCG), have been extensively studied for their capacity to enhance Akt phosphorylation, preserve IRS-1/2 activity, and stimulate GLUT4 translocation to the plasma membrane, thereby facilitating glucose uptake in skeletal muscle and adipose tissue [68]