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Research has characterised Tirzepatide’s beta cell incretin biology — examining the additive versus synergistic insulin secretory responses from co-stimulation of GIPR and GLP-1R relative to selective monoagonism at either receptor, the glucose dependency of dual incretin-driven insulin secretion, first and second phase insulin secretory dynamics under dual receptor occupancy, and beta cell trophic biology under sustained Tirzepatide GIPR and GLP-1R co-stimulation

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The condition, known as peripheral neuropathy, can be serious, and cause permanent loss of sensation