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What separates them clinically: Anhedonia is a reward-processing deficit: the brain’s dopaminergic system fails to generate or register pleasure, even when external rewards are present
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Brain-resident immune cells and their responses to stroke Microglia Stroke onset rapidly induces neuroinflammation, brain oedema, and oxidative stress, particularly following vessel occlusion, which markedly increases reactive oxygen species (ROS) production and damages endothelial cells forming the blood-brain barrier (BBB), thereby compromising its integrity (Lipton, 1999)