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People with a larger initial decline often notice changes sooner, while mildly deficient individuals may see gentler shifts over a longer period

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Meanwhile, MA treatment induced alterations in both gene expression levels and m6A methylation levels of genes related to the lysosome ( Fuca2 , Galc , Mcoln1 , Naglu , Slc11a2 , and Wdr7 ), autophagy ( C9orf72 , Irs1 , and Tsc1 ), and adherens junction ( Tcf7l2 ) (Figure 9A)