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Cells expressing MRP1 were hypersensitive to verapamil mixed with L-BSO while cells expressing MRP2 showed a sensitivity similar to control cells (Fig
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performed a meta-analysis and found that sperm DNA damage had a negative impact on IVF clinical pregnancy rates but did not affect the IVF and ICSI fertilization and the ICSI clinical pregnancy.[125] Another meta-analysis by Zini et al ., evaluating the influence of sperm DNA damage on spontaneous pregnancy loss after IVF and ICSI, showed the detrimental effect of sperm DNA damage on ART outcomes and suggested a clinical test to evaluate the DNA damage before IVF or ICSI procedures.[126] However, the Practice Committee of the American Society for Reproductive Medicine concluded that the data in the existing literature does not support the adverse consequences of sperm DNA damage on ART and natural pregnancy outcomes, but recommends future research to validate the clinical utility of sperm integrity tests.[127] A more recent meta-analysis by Simon et al
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