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Mechanistically, both compounds compromise epithelial barrier integrity, alter gut microbial composition, reduce SCFA production and disrupt hepatic metabolism primarily through MAPK- and NF-κB-dependent pathways, largely independent of sphingolipid disruption (Li et al., 2021b

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This discovery reveals a previously unknown direct link between neurotransmitters and iron metabolism, suggesting that in brain regions rich in dopaminergic neurons, iron metabolism in macrophages/microglia may be uniquely regulated by the local neurochemical environment (245)

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