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However, once the microglia become fully activated, there is a hyperreaction with an intense presentation of inflammation and excitotoxicity that exceeds that normally associated with microglial activation.[175] This link between inflammatory mechanisms and glutamate receptors works in both directions, that is, inflammation triggers the release of excess glutamate, and likewise, excess extracellular glutamate can trigger inflammation, making this association a self-propagating pathological process

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Furthermore, Frijhof et al