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Pyruvate kinase activators: targeting red cell metabolism in sickle cell disease - PMC

Am J Med 2011;124( PubMed Bergqvist-Karlsson, A., Thelin, I., and Bergendorff, O

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The 2AB that is formed when 2-oxobutyric acid accepts an amino group is abundant in the liver and is a good substrate for the γ-GCS reaction instead of Cys