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However, the protection phenotype observed in Tert deficient mice in the bleomycin-induced lung fibrosis was similar with mice from 2nd and 4th generation despite shortening of the telomeres

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Assembly of the middosome induces association and activation of the E3 ubiquitin ligase TNF receptor-associated factor 6 (TRAF6) which can trigger several different pathways (Pereira and Gazzinelli, 2023)