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However, in the year 2022, the IARC projected that by 2040, the burden of breast cancer is expected to increase, with projections to more than 3 million new cases per year and more than 1 million deaths per year (40% and 50% increase, respectively)

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Together, these studies suggest that hPrdx6 inhibition might be exploited as a therapeutic strategy to sensitize cancer cells to ferroptosis, but further studies are still needed to validate hPrdx6 as a biological target for cancer treatment [26, 35, 36]