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Preconditioning of encapsulated pancreatic islets with GHRHR agonists significantly enhanced graft function by improving glucose tolerance and increasing beta-cell insulin reserve in diabetic rats ( Interestingly, GHRH stimulated and GHRH antagonist inhibited the expression of the major antioxidant enzymes in the LNCaP human prostate cancer line ( Based on these studies, we suggest that GHRHR analogs have the potential to enhance beta-cell function, proliferation, and survival in vivo

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10.1073/pnas.84.1.136 [DOI] [PMC free article] [PubMed] [Google Scholar] Li Y