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In terms of outcome assessment, 18 (6.8%) studies applied DHTs to facilitate timely evaluation of therapeutic interventions, including patient-reported outcomes and digitally captured functional measures

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GLP-1 Agonists: Treatment Failure Does Not Preclude Prevention The November 2025 announcement from Novo Nordisk that oral semaglutide failed to slow Alzheimer’s progression in the EVOKE and EVOKE+ trials was widely reported as a setback