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Since extracellular NAD + can be degraded into adenosine, extracellular NAD + might exert some of its effects via adenosine, which can induce profibrotic effects via adenosine receptor A2a on dermal fibroblasts 60

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1,2 This post hoc analysis assessed efficacy and safety of IV GLM in AS pts with early disease (ED) vs late disease (LD) based on pt-reported duration of inflammatory back pain (IBP)