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However, no constitutively active Rho GTPase mutations have been found in human cancers (Rihet et al., 2001

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101 Microbial translocation and establishment of the hepatic immune microenvironment In advanced liver diseases like cirrhosis, gut barrier function is severely impaired, leading to massive translocation of live bacteria and their products (such as LPS) to the liver, directly participating in shaping the local immune microenvironment