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TGR5: pathogenetic role and/or therapeutic target in fibrosing cholangitis

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It is likely that some steps of the biotransformation of arsenic that involve the formation of glutathione-bound species can occur also involving individual cysteine thiol groups or pairs of vicinal thiol groups in proteins, such as the catalytically essential thiol groups of enzymes and the regulatory elements of effector proteins that can be modulated by reversible glutathionylation (see further)