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Using nuclear magnetic resonance (NMR)-based metabolomics to obtain serum metabolic profiles of doxycycline-treated ( n = 60) and standard therapy of COPD patients ( n = 40), doxycycline (100 mg) significantly increased the values of FEV1/forced vital capacity (FVC) and improved the COPD assessment test (CAT) scores after 3 months’ treatment

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ATRX loss is associated with alternative lengthening of telomeres, a hallmark of genomic instability, and is predominantly observed in LGGs with IDH mutations and without 1p/19q codeletion