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In addition to the modulation of ketone metabolism, a recent in vitro study employing metabolomics, lipidomics, and proteomics analyses revealed that empagliflozin, an SGLT2i, influences lipid accumulation, including the restoration of DHA levels, in the AC16 human cardiomyocyte cell line treated with high glucose [225], suggesting a cell-autonomous effect of SGLT2i on mitigating lipotoxicity
Farmaci Antinfiammatori e Antidolorifici
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HIF-la plays a critical role in cell survival during low oxygen as HIF-la induces expression of pyruvate dehydrogenase kinase 1 and most major genes involved with glucose uptake, glycolysis, and lactic acid production [127]
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