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Gliotoxin incubation with A459 cells can induce the secretion of proinflammatory cytokines, including IL-4, IL-8, and IL-10, whereas the upregulation of IL-6 and IL-8 cytokines was observed in gliotoxin-treated L132 cells, with only IL-8 upregulation observed in A459 and L132 cells treated with fumagillin [34,47]

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Therefore, one would predict that modulating this pathway would affect parasite growth and development