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Patients often present with mild to moderate symptoms, and epithelial cell proliferation is observed via endoscopy, which may be accompanied by colonic swelling

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Safety Toxicity A number of possible problems with very large doses of vitamin C have been suggested, mainly based on in vitro experiments or isolated case reports, including genetic mutations, birth defects, cancer, atherosclerosis, kidney stones, "rebound scurvy," increased oxidative stress, excess iron absorption, vitamin B12 deficiency, and erosion of dental enamel