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Additionally, increased expression of enzymes such as ACSL4 and LPCAT3 promotes the incorporation of polyunsaturated fatty acids (PUFAs) into phospholipids, sensitizing membranes to peroxidation [209, 210]

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Neuronal vulnerability and sensitivity to 1-methyl-4-phenylpyridinium (MPP + ) and rotenone was significantly increased in the overexpression of WT and D620N VPS35 models (Wang et al., 2014)