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In addition to their differentiation capabilities, a reduction in pro-inflammatory cytokines (IL-6, IL-8, TNF-α) has been observed following the injection of MSCs, indicating that MSCs secrete immunomodulatory factors through paracrine effects to create a favorable microenvironment (Xie et al., 2021)
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ʟ-carnitine-fed C57BL/6 J mouse model The handling of animals complied with the guidelines of the Institutional Animal Care and Use Committee of National Taiwan University (approval number: NTU107-EL-00170 and NTU107-EL-00084)