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For example, SLC7A11 provides resistance to BRAF and MEK inhibitors in BRAF V600E mutant melanoma, geldanamycin resistance in lung cancer, cisplatin resistance in gastric cancer, temozolomide resistance in glioma and gemcitabine resistance in pancreatic cancer (84–89)
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AICAR, the AMPK-activating exercise-mimetic candidate, increased running endurance in sedentary mice by 44% in the well-known 2008 Cell study [14] — and then, in a randomised Phase 3 cardiac-surgery trial stopped for futility after 3,080 of a projected 7,500 patients had been randomised, produced a primary-outcome rate of 5.1% versus 5.0% on placebo [15]