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In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP

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Clinical studies have revealed significantly elevated levels of malondialdehyde (MDA) and advanced oxidation protein products (AOPP) and reduced levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) in BALF from children with MPP, forecasting that advanced oxidation protein products may serve as predictive biomarkers for disease severity in SMPP and RMPP (C-index = 0.960 (95% confidence interval 0.958–0.963) (138)