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Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice - ScienceDirect

Discovery of a covalent inhibitor of KRAS(G12C) (AMG 510) for the treatment of solid tumors

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Genetic ablation of Gpx4 or disruption of cystine uptake via system xc - is sufficient to induce cell death with hallmark lipid peroxidation signatures, whereas this process can be selectively suppressed by lipophilic antioxidants (e.g., ferrostatin-1 and liproxstatin-1) or iron chelators (e.g., deferoxamine) [14,116-118]