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Molecular Basis of Disease, Elsevier 1739 , 5–25, doi:10.1016/j.bbadis.2004.08.004 (2004)

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A more recent study found that the MTHFR C677T allele (rs1801133) significantly reduced the methionine-dependence index of lymphocytes, a measure of viable cell number between methionine-complete and methionine-free media [27]