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Poster Session I - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.02 - GENETICS, ‘OMICS AND BIOMARKERS P451 - ESOC25-1378 GENETIC INSIGHTS INTO PROTECTIVE EFFECTS OF GLP-1 RECEPTOR AGONISTS ON STROKE AND ALZHEIMER’S DISEASE RISK IN EUROPEAN AND EAST-ASIAN POPULATIONS Ilana Caro 1 , Muralidharan Sargurupremraj 2 , David-Alexandre Trégouët 3 , Daichi Shigemizu 4,5 , Thierry Couffinhal 6,7 , Yoichiro Kamatani 8 , Kamel Mohammedi 6,9 , Stéphanie Debette 3,10 1 Bordeaux Population Health research center, Inserm, UMR U1219, Université de Bordeaux, Bordeaux, France, 2 Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, United States, 3 Bordeaux Population Health research center - Université de Bordeaux, Bordeaux, France, 4 Medical Genome Center, National Center for Geriatrics and Gerontology, Aichi, Japan, 5 Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan, 6 Inserm, Biologie Des Maladies Cardiovasculaires, U1034, Université de Bordeaux, Bordeaux, France, 7 Department of Cardiology, CHU de Bordeaux, Bordeaux, Bordeaux, France, 8 Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan, 9 Department of Endocrinology, Diabetology and Nutrition, CHU de Bordeaux, Bordeaux, France, 10 Department of Neurology, Institute for Neurodegenerative Diseases, CMRR, CHU de Bordeaux, Bordeaux, France Background and Aims: Stroke and dementia are leading causes of death and disability worldwide requiring enhanced preventive strategies