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The amylin domain: what makes Amycretin more than a GLP-1 agonist The amylin receptor is not a single dedicated gene product — it is a heterodimer formed when the calcitonin receptor, a class-B GPCR, pairs with one of three receptor-activity-modifying proteins (RAMP1, RAMP2 or RAMP3), producing three subtypes (AMY1, AMY2, AMY3) with overlapping but distinct tissue distribution (Bagger et al., Frontiers in Endocrinology, 2021)

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[189] Despite its survival benefits, use of beta blockers in eligible patients remains suboptimal