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Considering that the functional activation of Nrf2 is driven by its translocation into the nucleus, the modest elevation of Nrf2 observed here in whole muscle homogenates could indeed correspond to a substantial increase at the nuclear compartment, thereby having a more pronounced effect on antioxidant gene expression

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That behavior is "particularly troublesome" for acetaminophen, an FDA report said, because the drug's narrow safety margin places "a large fraction of users close to a toxic dose in the ordinary course of use.” The FDA sets the maximum recommended daily dose of acetaminophen at 4 grams, or eight extra strength acetaminophen tablets

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