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27 Metabolic maps are available that annotate the gene encoding for any given enzyme, the kinetic parameters for each substrate, the required co-factors, the allosteric regulators, but the simple measurement of enzyme expression and of metabolite levels is not sufficient to indicate which metabolic pathway is utilized in any given cell and at any given time

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39,40,41,42 Similarly, patients with a history of drug or alcohol abuse were excluded by 61% of trials