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PLoS Pathog (2010) 6(11):e1001191.10.1371/journal.ppat.1001191 282 WitzenrathMPacheFLorenzDKoppeUGutbierBTabelingCet alThe NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia

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These effects are believed to be partially mediated by enhanced BDNF signaling and reduced systemic inflammation, making BPC-157 of interest not only for physical injury recovery, but also for patients experiencing chronic stress, anxiety, or medication-induced neuroinflammation