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Figure 3 4.2.1 Lipid peroxidation and macrophage Macrophages are an important component of the immune system and can be polarized into classically activated macrophages (M1) or alternatively activated macrophages (M2) in response to microenvironmental signals ( As macrophages are phagocytic immune cells and usually produce ROS in digesting dying cells or microorganisms ( Alox5 gene and can oxygenate polyunsaturated fatty acids to lipid peroxides ( (Nos2 -/- ) or wild-type bone marrow cells into irradiated recipient mice followed by Lewis lung carcinoma establishment, mice reconstituted with NOS2-deficient bone marrow cells had fewer M1 and similar numbers of M2 macrophages than mice reconstituted with bone marrow from wild-type mice

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