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Maternal Caffeine Consumption during Gestation and Lactation Abolishes Cortical Oxidative Stress and Restores Na+/K+-ATPase Activity in Neonates Exposed to Hyperthermia-Induced Seizures

Treatment significantly reduced insulin resistance and serum insulin levels

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Furthermore, these data contribute to understand why some ferroptosis-targeting strategies are highly efficient to reduce ATN [9, 29], whereas others highlight a disconnect between potent ferroptosis-modulating effects observed in cell culture and the comparatively modest impact of such interventions in AKI in vivo, exemplified by FSP1 deficiency [6, 9, 10]