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Tirzepatide, while highly effective, can also cause gastrointestinal side effects similar to other GLP-1 receptor agonists
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While the CNS is generally considered protected from peripheral aAB by an intact BBB, it may be vulnerable to autoimmune attack during states of peripheral inflammation or endothelial dysfunction that disrupt the BBB and thus allow for increased antigen presentation and immigration of immune cells (Lampron et al., 2013