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Inhibition of cell death by blocking Src kinase (e.g., PPI)

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Studies in the SAMP1 mouse model showed that supplementation with glucoraphanin-enriched kale (GEK) significantly slows these processes through a multidirectional effect: activation of the Nrf2 pathway (increasing HO-1 and NQO1 expression), inhibition of Smad7 (which releases the TGF-β/Smad3 pathway and stimulates type I collagen synthesis), and improvement of ECM architecture (increasing elastin and hyaluronic acid levels)