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Nicotinamide N-Methyltransferase (NNMT) and Liver Cancer: From Metabolic Networks to Therapeutic Targets

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By attenuating NNMT activity, 5‑Amino‑1MQ has been observed in preclinical settings to elevate NAD+ availability, enhance metabolic flux, and upregulate downstream signaling programs associated with cellular stress responses and energy expenditure (e.g., SIRT1)