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However, the brain poses unique challenges for gene therapy, and the development of effective delivery carriers is a significant focus of current research

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Of note, there are at least five other mechanisms besides secondary neuroinflammation by which COVID can affect the CNS (direct viral invasion of neural tissue, autoimmunity, reactivation of herpesviruses, neurovascular dysfunction, the sequelae of hypoxic, and other metabolic disturbances), which may occur exclusively or in combination in some individuals with varying frequency and timing (for review, see [88])