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Notably, the effects seen in rodents may not extrapolate directly to humans

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In spontaneously hypertensive rats, the hypotensive effect of ginger extract is suggested to be associated with vascular relaxation mechanisms via activation of cGMP-KATP channels, nitric oxide and prostacyclin release, transmembrane calcium channel or Ca 2+ release from intracellular stores, and stimulation of muscarinic receptors (Razali et al