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While there is still a lot of research needed to understand the underlying biology, the above observations suggest a close relationship between lipedema, obesity and lymphedema, as well as a physiological rationale for why lipedema can appear to progress to more advanced disease and “lipo-lymhedema”

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examining a multi-peptide topical formulation in women over 60 found statistically significant improvements in skin firmness and elasticity after 16 weeks, with histological confirmation of increased dermal collagen density one of the relatively few studies to include biopsy evidence of structural change in a clinically aged population

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