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Nevertheless, as all of these studies assessed only the average levels of methylated DNA in a population of cells, further technical advances will hopefully allow us to shift our attention from epigenome changes in a population of cells grown in vitro toward single cells in their intact niche
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pH of the medium should also be carefully selected to cater to the need as per the pH of the drug formulation, pH solubility profile of the active and also pH of the target membrane
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