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Studies and long-term observations suggest that: Up to 60% of patients may experience more attacks within one year if uric acid remains uncontrolled Over time, the frequency of attacks may increase in some individuals Most patients are appropriately treated with Uric acid–lowering medicines (such as allopurinol or febuxostat) Anti-inflammatory medicines during acute attacks Pain relievers Occasionally injectable medication when pain is severe These have an important role, especially during acute episodes

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[DOI] [PubMed] [Google Scholar] 359.Hughes M, Machardy S M, Sheppard A J, Woods N C