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Among the genetic causes, germ line mutations in the tumor suppressor genes BRCA1 and BRCA2 , involved in maintaining genome integrity, are the most well-known genetic risks [137,138,139], and among epigenetic factors, aberrant DNA methylations in promoter regions and histone acetylations are involved in breast cancer development and therapeutic resistance [140,141,142,143]

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Rational design of a biomimetic cell penetrating peptide library