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Numerous studies have thoroughly elucidated the specific molecular mechanisms by which maneb exposure induces apoptosis (Figure 3), including disruption of intracellular Mn 2+ and Zn 2+ homeostasis, interference with lipid and xenobiotic metabolism, activation of Bcl-2 family proteins, and caspase-3/9-mediated intrinsic apoptotic pathways (70, 98, 99)
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