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[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Goyer RA, Toxic and Essential Metal Interactions, Annu

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This framework established a long-standing, strictly neuron-centric interpretation of brain function, in which synapses and neuronal circuits were regarded as the exclusive substrates of cognition, behavior, and neuropathology, while glial cells were erroneously sidelined, commonly described as passive “supportive” or “cementing” elements, reflecting the entrenched view that their role was ancillary to neuronal activity rather than mechanistically relevant to CNS function