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Parental ZR-75-1 cells were cultured in Phenol-red free medium containing 10% Dextran-coated charcoal-stripped FBS (DCC) with increasing concentration of Tamoxifen, starting from 0.5 μM initially, and finally up to 5 μM in a period of about 6 months

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Furthermore, several plants, including Hippophae rhamnoides , Centella asiatica , Aloe vera and others, along with their extracts, are investigated for their significant role in mitigating the toxic effects caused by HMs [7]